Tesamorelin + Ipamorelin Blend

Suits people researching deep abdominal fat and the growth hormone axis who want the strongest-evidenced GHRH peptide rather than the lighter blends. It is a natural step up for anyone who found a CJC-1295 based blend too mild, since tesamorelin is the better-documented half. Best for those comfortable that the evidence sits with each compound separately, that tesamorelin's trial data come from one specific patient population, and that the pairing itself rests on mechanism rather than a trial. Like other growth hormone peptides, both are on anti-doping lists.

Two receptors, two different signalling systems. Tesamorelin is a stabilised full-length GHRH analogue: it binds the GHRH receptor on the pituitary and raises pulse amplitude, and a chemical modification protects it from the enzyme that breaks down natural GHRH, stretching its working life to roughly half an hour. Ipamorelin binds the ghrelin receptor instead, which drives the pulse directly, recruits the body's own GHRH, and acts against somatostatin, the signal that normally shuts growth hormone release down. Given alone, each one runs into the limit the other removes. Human studies of this receptor pairing (Bowers and colleagues, 1990 onward) showed the combination produces more growth hormone than the two added together. Those studies used older peptides rather than ipamorelin specifically.

The reported effects are those of the growth hormone class generally, and most are mild and dose related: fluid retention and puffiness, joint aches, muscle aches, injection site reactions, and tingling or carpal-tunnel-type symptoms in the hands, which are driven by the fluid retention. Growth hormone works against insulin, so blood sugar is the thing to watch on long runs, though tesamorelin's trials found no meaningful change over 12 weeks in people with type 2 diabetes and no glycaemic difference in the pivotal trial. The sensible ceiling is keeping IGF-1 inside the normal range for your age rather than pushing above it. Long-term data for the two used together does not exist. Purity matters, and a Certificate of Analysis is shared where our supplier provides one.

Supplied freeze-dried. Reconstitute with bacteriostatic water, then refrigerate at 2-8°C and keep it out of the light. Our 25 mg pen holds 20 mg tesamorelin plus 5 mg ipamorelin; reconstituted to 2 ml that gives 12.5 mg/ml, where 10 clicks delivers 1 mg tesamorelin plus 250 mcg ipamorelin. The ratio is fixed, so the two always rise and fall together. Dose subcutaneously, fasted, and pre-bed is the usual slot. We can reconstitute to spec for you as a paid service, or fill a pen.