Retatrutide
Dosage20mg
Rp 3.990.000per vial
Cold-chain delivery to your door around Bali. Pens and bacteriostatic water available, just ask.
- Class
- Triple agonist (GLP-1 / GIP / glucagon)
- Half-life
- ~6 days (reported)
Also known as LY3437943, RETA
Tested in large, late-stage human trials, but not an approved medicine.
large human trials confirmed for obesity (human trialsprogramme); early human trials for type 2 diabetes and fatty-liver disease. Not an approved medicine; no long-term cardiovascular-outcome data yet.
About this peptide
Retatrutide is the newest and most potent of the weight-research peptides. It acts on three hunger and metabolism pathways at once (GLP-1, GIP and glucagon), where Tirzepatide hits two and Semaglutide one. In published early human trials and large human trials it has produced the largest weight reductions reported for this class. Supplied as a freeze-dried powder for research use.
What it does
Researched for fat loss and metabolic health, but in practice people use it across a wide range. Some are after significant weight reduction, often when Tirzepatide or Semaglutide has plateaued. Just as many now use it for everyday maintenance: quietening 'food noise' so eating well is effortless, holding low body fat at maintenance or a light deficit, and still feeling good and training hard. The glucagon component also raises energy expenditure, which sets it apart from the dual and single agonists.
What to expect
Week 1
Appetite suppression within 24-72 hours; mild initial nausea
Weeks 2-4
digestive effects peak during dose-escalation steps; weight loss modest so far
Weeks 4-12
digestive settles at a stable dose; resting heart rate begins to rise; appetite suppression stabilises
Long term
In large human trials, weight loss continued without plateau through 80-104 weeks at the higher doses
A rough guide drawn from research and community reports. Individual results vary and nothing here is a promise.
Reported effects
Reported benefits
Side effects & cautions
Key points
Suits a broad range: people chasing large weight goals, often stepping up when Tirzepatide or Semaglutide has stalled, as well as those who just want easy appetite control and an effortless lean maintenance. It's also a perfectly good entry point for those newer to peptides, eased in gently to start.
It mimics three gut and metabolic hormones together: GLP-1 and GIP curb appetite and improve how the body handles glucose, while glucagon-receptor activity raises resting energy expenditure and drives liver fat reduction. Acting on all three is what researchers link to its outsized effect on body weight.
Gastrointestinal effects, mainly nausea, are the most commonly reported and track with how fast the amount is raised. The glucagon component tends to raise resting heart rate. As with any freeze-dried peptide, purity and correct reconstitution matter, and a Certificate of Analysis is shared where our supplier provides one.
Supplied freeze-dried. Reconstitute with bacteriostatic water to your required concentration, then refrigerate at 2-8°C; unmixed vials are stable kept cool and dark. Smaller vials help ensure the reconstituted peptide is used within its stable window. We can reconstitute to spec as a paid service, or fill a pen.
- Blood pressure
- Typically lowers modestly alongside weight loss
- Heart rate
- Raises resting heart rate, usually 5-10 beats per minute and sometimes more
- Blood sugar
- Lowers; asymptomatic hypoglycaemia possible
- Lipids / cholesterol
- Improved - triglyceride reduction at higher doses
What studies and users commonly report happening to these markers. Research context only, not medical advice.
Questions about Retatrutide
Retatrutide acts on three pathways including glucagon, where Tirzepatide acts on two. Trial weight reductions have been larger, and many people move to it when Tirzepatide plateaus. It is newer, with less long-term data.
It tends to raise resting heart rate, often by 5-10 beats per minute. If you are sensitive to heart-rate changes, that is worth knowing before you start.
Evidence
Further reading
Want to go deeper? We've written up the research on this.
Sourcing
Sourced carefully from vetted suppliers. Where a Certificate of Analysis is available we share it on request, and we'll always tell you what we have for your batch.
For Research Use Only
Sold strictly for laboratory and research purposes. Not for human or veterinary use, not a medicine, and not for diagnostic or therapeutic application.
